刘志国，教授，博士生导师（植物学），主要研究方向为①林源活性物质的提取、分离和利用技术。②林源活性物质与体内生物大分子的相互作用研究。2006年于中国科学院长春应用化学研究所获理学博士学位。2010-2013年在浙江海正集团有限公司与东北林业大学生物学博士后流动站完成了研究工作顺利出站，2013年8月至2014年8月在美国加州大学戴维斯分校生物医学工程系访问学习，2014年晋升为教授。2006年至今承担了本科生和研究生课程的教学工作，主讲的课程有《药物的波谱及结构鉴定》、《分析化学》、《植物化学》、《Properties and Analysis of Matter》等主干课程。在博士后流动站研究期间与药业企业进行了深入合作研究。在林源植物药物的多功能纳米抗肿瘤制剂的开展了大量研究，对紫杉醇的化学交联药物开展了探索研究，相关成果发表于Bioorganic chemistry 83 (2019) 154-160。近年来，主持各级各类项目多项，科研经费200余万元，科学出版社出版学术专著1部，发表SCI文章60余篇，获得省部级奖励一项。
联系邮箱： zhiguoliu@163.com
联系电话： 0451-82190224
所在学科
药学学科生药学方向（学硕），材料与化工（专硕），植物学（博士点）
主持和参与的科研项目：
1.国家重点研发项目子课题，2022YFD2200604-2,林源特色黄酮类成分的提取分离、结构修饰与作用机制研究，2022-11至2026-10，在研，主持
2.中央高校基本科研业务费专项资金项目，2572020DR07，东北红豆杉资源高值化利用与产业化示范、2020-10至2023-09，在研，主持
3.黑龙江省自然科学基金, JJ2019LH0951, 新型铂类抗癌配合物与DNA及相关蛋白形成关键结构的研究, 2019-01至2021-12,在研,主持
4.中央高校基本科研业务费专项资金项目，2572018CT01，森林植物资源活性成分高值化利用应用基础研究、2018-05至2021-04，结题，主持
5.国家自然基金面上项目，31770619，多孔纤维素基紫衫类成分分子印迹材料的构建、表征及识别机制研究、2018-01至2021-12，在研,参加
6. 十三五国家重点研发计划课题子课题, 2016YFD0600805-01-06，林源活性成分中生物碱类、黄酮类制剂研制, 2016-07至2020-12，结题，主持
7. 悦禾科技生态有限责任公司横向课题，植物多酚新型抗肿瘤药物制剂的研究，2016-06至2020-09，在研，主持
8. 哈尔滨市科技创新人才项目，2015RQQXJ053，紫杉烷类抗癌药物新型蛋白制剂的制备和应用，2015-09至2018-09，7.5万元, 已结题,主持
9. 黑龙江省自然科学基金, LC2015008,铂类抗癌配合物抗癌机制中关键结构的探索研究, 2015/07-2018/07, 已结题,主持
发表文章
1) Green synthesis, characterization and antibacterial study on the catechin functionalized ZnO nanoclusters. Baihan Zhao, Shixian Deng, Jingchao Li, Congcong Sun, Yujie Fu and Zhiguo Liu*. Mater. Res. Express 8 (2021) 025006
2) Green synthesis of proanthocyanidins-functionalized Au/Ag bimetallic nanoparticles.Shixian Deng*, Baihan Zhao, Yayan Xing, Yuzhe Shi, Yujie Fu and Zhiguo Liu*. Green chemistry letters and reviews 14(2020) 43-48.
3) Synthesis of proanthocyanidins-functionalized Fe3O4 magnetic nanoparticles with high solubility for removal of heavy-metal ions. Yuzhe Shi , Yayan Xing , Shixian Deng, Baihan Zhao, Yujie Fu, Zhiguo Liu*. Chemical Physics Letters 753 (2020) 137600
4）Hydrothermal synthesis of Ag nanoparticles on the nanocellulose and their antibacterial study. Xuewei Zhang, Haiyao Sun, Shengnan Tan, Jing Gao, Yujie Fu, Zhiguo Liu*. Inorganic Chemistry Communications 100 (2019) 44–50. (SCI,IF=1.810)
5）Preparation, characterization and in vitro activity of a docetaxel-albumin conjugate. Gao, Jing; Jiang, Shougang; Zhang, Xuewei; Yujie Fu, Zhiguo Liu* ,Bioorganic chemistry 83 (2019) 154-160.(SCI,IF=4.831)
6）Jiang, Shougang; Liu, Zhiguo; Wu, Lei;Tumor targeting with docosahexaenoic acid-conjugated docetaxel for inhibiting lung cancer metastasis to bone. ONCOLOGY LETTERS 16(2018) 2911-2920
7) Linhai Biao, Shengnan Tan, Xuewei Zhang, Jing Gao, Zhiguo Liu*, Yujie Fu, Synthesis and characterization of proanthocyanidins-functionalized Ag nanoparticles, Colloids and Surfaces B: Biointerfaces 169 (2018) 438–443. （SCI）IF=4.389
8）Linhai Biao, Shengnan Tan, Qinghuan Meng, Jing Gao, Xuewei Zhang, Zhiguo Liu* and Yujie Fu*, Green Synthesis, Characterization and Application of Proanthocyanidins-Functionalized Gold Nanoparticles, Nanomaterials,2018, 8, 53 （SCI）IF=4.034
9）Chengbo Gu, Linan Fu, Xiaohan Yuan, Zhiguo Liu, Promoting Effect of Pinostrobin on the Proliferation, Differentiation, and Mineralization of Murine Pre-osteoblastic MC3T3-E1 Cells, Molecules 2017, 22, 1735
10) Fengjie Xu, Linhai Biao, Yuangang Zu ,Zhiguo Liu*, Study on Interactions between Paeonol and Cadherin, Chinese Journal of Analytical Chemistry,2017,45,1025-1030.
11) Linhai Biao, Shengnan Tan, Yuanlin Wang, Ximin Guo, Yujie Fu, Fengjie Xu,, Yuangang Zu, Zhiguo Liu*, Synthesis, characterization and antibacterial study on the chitosan-functionalized Ag nanoparticles, Materials Science and Engineering C,2017, 76: 73-80. （SCI=5.880）.
12)Yongpeng Zou，Linhai Biao, Fengjie Xu, Ruisi Liu, Zhiguo Liu*，Yujie Fu，Structural study on the interactions of oxaliplatin and linear DNA，Scanning，2016，38：880-888.（SCI）.
13) Zhiguo Liu*, Fengjie Xu, Yuangang Zu,, RonghuaMeng and Wenjie Wang Study on Water-Dispersible Colloids in Saline-Alkali Soils by Atomic Force Microscopy and Spectrometric Methods, Microscopy Research and Technique ,2016,79:525-531. （SCI）
14) Fengjie Xu, Ruisi Liu, Linhai Biao, Yuangang Zu, and Zhiguo Liu*. Study on the Interactions Between Anti-Cancer Drug Oxaliplatin and DNA, Progress in Biochemistry and Biophysics 2016,43: 684-690. （SCI,封面文章）（SCI）
15） Leipeng Li, Ruisi Liu, Fengjie Xu, Yuangang Zu, Zhiguo Liu*. Study on the interactions between anti-cancer drug oxaliplatin and DNA by atomic force microscopy. Micron ,2015,76:46–51.（SCI）.
16) Zhiguo Liu*, Ruisi Liu, Zhen Zhou, Yuangang Zu, Fengjie Xu, Structural changes of linear DNA molecules induced by cisplatin. Biochemical and Biophysical Research Communications ,2015, 457:688-692.（SCI）
17) Xiao Peng, Haoran Fu, Ruisi Liu,Lin Zhao, Yuangang Zu, Fengjie Xu, Zhiguo Liu*Adsorption of Human Serum Albumin Onto Highly Orientated Pyrolytic Graphite Surface Studied by Atomic Force Microscopy. Scanning,2015, 37:158–164.（SCI）
18) Zhiguo Liu*, YuanlinWang,, Yuangang Zu, Yujie Fu, Na Li, Na Guo, Ruisi Liu, Yiming Zhang. Synthesis of polyethylenimine (PEI) functionalized silver nanoparticles by a hydrothermal method and their antibacterial activity study. Materials Science and Engineering C ,2014, 42: 31-37.（SCI）
19) Zhiguo Liu*, Lin Zhao, Yuangang Zu, Shengnan Tan，Yuanlin Wang, Yiming Zhang，Unusual DNA structures formed on bare highly oriented pyrolytic graphite surfaces studied by atomic force microscopy. Microscopy and Microanalysis, 2013, 19: 544–552.（封面文章,SCI）
20）J Yu, Q Xu, Zhiguo Liu*, X Guo, S Han, S Yuan , L Tong.Morphological characteristics of fulvic acid fractions observed byatomic force microscopy. Journal of Microscopy ,2013, 252:71–78.（SCI）
21) Zhiguo Liu*, Lin Zhao, Zhen Zhou, Tongze Sun, Yuangang Zu, Assembly of Single-Stranded DNA onto HOPG Surface at Different Temperature: Atomic Force Microscopy Study. Scanning, 2012, 34:302–308.（SCI）
22) Zhiguo Liu* , Zhimin Xing, Yuangang Zu , Shengnan Tan, Lin Zhao, Zhen Zhou, Tongze Sun, Synthesis and characterization of L-histidine capped silver nanoparticles. Materials Science and Engineering C, 2012,32:811–816.（SCI）
23) Lin Zhao, Zhiguo Liu*, Yuangang Zu, Zhen Zhou, Tongze Sun, Influence of Mg2+, Ni2+, and Cu2+ on DNA assembly on HOPG surfaces: atomic force microscopy study. Scanning, 2012,34: 68-75. (SCI）
24) Zhiguo Liu, Yuangang Zu, Ronghua Meng, Zhimin Xing, Shengnan Tan, Lin Zhao, Tongze Sun and Zhen Zhou, Adsorption of Humic Acid onto Carbonaceous Surfaces: Atomic Force Microscopy Study. Microscopy and Microanalysis, 2011, 17:1015-1021.（SCI）
25) Shengnan Tan, Zhiguo Liu*, Yuangang Zu, Yujie Fu, Zhimin Xing, Lin Zhao,Tongze Sun, Zhen Zhou . Adsorption of chitosan onto carbonaceous surfaces and its application: atomic force microscopy study, Nanotechnology, 2011, 22:155703 (8pp). （SCI）
26) Wenjie Wang, Haisheng He, Yuangang Zu, Guan Yu , Zhiguo Liu, Zhonghua Zhang, Huinan Xu, Xingyang Yu, Addition of HPMA affects seed germination, plant growth and properties of heavy saline-alkali soil in northeastern China: comparison with other agents and determination of the mechanism. Plant and Soil, 2011,339:177-191. （SCI）
27) Zhiguo Liu, Yuangang Zu, Yujie Fu, Ronghua meng, Songling Guo , Zhimin Xing, Shengnan Tan. Hydrothermal Synthesis of Histidine-Functionalized Single-Crystalline Gold Nanoparticles and Their pH-Dependent UV Absorption Characteristic. Colloids and Surfaces B: Biointerfaces, 2010,76:311–316.（SCI）.
28) Zhiguo Liu*, Shengnan Tan, Yuangang Zu, Yujie Fu, Ronghua Meng, Zhimin Xing. The interactions of cisplatin and DNA studied by atomic force microscopy. Micron, 2010 ,41:833–839.（SCI）
29) Zhimin Xing , Zhiguo Liu*, Yuangang Zu, Yujie Fu , Chunjian Zhao , Xiuhua Zhao, Ronghua Meng, Shengnan Tan. Synthesis of camptothecin-loaded gold nanomaterials. Applied Surface Science, 2010,256:3917-3920.（SCI）
30) Nan Wu, Kong Yu,Yuangang Zu, Yujie Fu, Zhiguo Liu, Ronghua Meng, Xia Liu, Thomas Efferth, Activity investigation of pinostrobin towards herpes simplex virus-1 as determined by atomic force microscopy. Phytomedicine, 2010,18:110-118. （SCI）
31) Yuangang Zu, Su Zhang, Yujie Fu, Wei Liu, Zhiguo Liu, Meng Luo, Thomas Efferth, , Rapid microwave-assisted transesterification for the preparation of fatty acid methyl esters from the oil of yellow horn (Xanthoceras sorbifolia Bunge.). European Food Research and Technology, 2009 ,229: 43-49.（SCI）
32) Yujie Fu, LiYan Chen, YuanGang Zu, Zhiguo Liu, Xia Liu, LiPing Yao, Thomas Efferth, The Antibacterial Activity of Clove Essential Oil Against Propionibacterium acnes and Its Mechanism of Action. Archives of Dermatology 2009,145:86-88.（SCI）
33) Yujie Fu, Wei Liu, Yuangang Zu, Xiaoguang Shi, Zhiguo Liu, Gunter Schwarz,Thomas Efferth. Breaking the spores of the fungus Ganoderma lucidum by supercritical CO2. Food Chemistry ,2009,112 : 71–76.（SCI）
34) Zhiguo Liu, Ronghua Meng, Yuangang Zu, Qingyong Li, and LiPing Yao, Imaging and Studying Human Topoisomerase I on Mica Surfaces in Air and in Liquid by Atomic Force Microscopy. Scanning, 2009,31: 160-166.（SCI）
35) Zhiguo Liu, Yuangang Zu, Songling Guo. Synthesis of micron-scale gold nanochains by a modified citrate reduction method. Applied Surface Science, 2009,255:5827–5830.（SCI）
36) Zhiguo Liu, Yuangang Zu, Yujie Fu, Zhonghua Zhang, and Ronghua Meng. Assembling and Imaging of His-tag Green Fluorescent Protein on Mica Surfaces Studied by atomic force microscopy and Fluorescence Microscopy. Microscopy Research and Technique, 2008,71:802-809.（SCI）
37) Zhiguo Liu, Yuangang Zu, Yujie Fu, Yuliang Zhang, Huili Liang Growth of the oxidized nickel nanoparticles on a DNA template in aqueous solution. Materials Letters ,2008, 62,2315-2317.（SCI）
38) Zhiguo Liu ,Yuangang Zu Yujie Fu Songlin Guo Yuliang Zhang Huili Liang. Synthesis of the hybrid nanostructures composed of the copper ions and poly(p-phenylenediamine) in aqueous solutions. Journal of Nanoparticle Research, 2008,10:1271–1278.（SCI）
39) Zhiguo Liu, Yuangang Zu, Songlin Guo, Yujie Fu, Yuliang Zhang, Huili Liang. Synthesis of the hybrid porous rods and nanosheets composed of the nickel ions and poly(p-phenylenediamine) in aqueous solution. Materials Science and Engineering C, 2008, 28:1284–1288.（SCI）
40) Baoli Shi, Qianru Zhang, Hongfeng Zhang, Zhiguo Liu, Xiucheng Zhang .Concentration of Benzylpenicillin Sodium by Polyimide Nanofiltration Membrane. Journal of Applied Polymer Science , 2007,104:3077–3081 .（SCI）
41) Yonghai Song, Li Wang, Lanlan Sun, Gang Wei, Zhiguo Liu, Li Wang, Zhuang Li Large-scale, uniform DNA network on 11-mercaptoundecanoic acid modified gold (111) surface: Atomic force microscopy study. Microscopy Research and Technique 2007, 70:572-577.（SCI）
42) Yujie Fu, yuangang Zu, Liyan Chen, Thomas Efferth, Huili Liang, Zhiguo Liu, Wei Liu. Investigation of Antibacterial Activity of Rosemary Essential Oil against Propionibacterium acnes with Atomic Force Microscopy. Planta Med. 2007,73:1275-1280.（SCI）
43) Zhiguo Liu, Zhuang Li, Hualan Zhou, Gang Wei, Yonghai Song, Li Wang and lanlan Sun. Manipulation, Dissection, and Lithography Using Modified Tapping Mode Atomic Force Microscope. Microscopy Research and Technique, 2006,69:998-1004.（SCI）
44) Li Wang, Gang Wei, Lanlan Sun, Zhiguo Liu,Yonghai Song,Tao Yang ,Yujing Sun,Cunlan Guo,Zhuang Li, Self-assembly of cinnamic acid-capped gold nanoparticles,Nanotechnology, 2006,17: 2907-2912.（SCI）
45) Li Wang, Gang Wei, Bin Qi, Hualan Zhou, Zhiguo Liu, Yonghai Song, Xiurong Yang and Zhuang Li. Electrostatic assembly of Cu2O nanoparticles on DNA templates. Applied Surface Science, 2006,252: 2711-2716. （SCI）
46) Lanlan Sun, Gang Wei, Yonghai Song, Zhiguo Liu, Li Wang and Zhuang Li. Fabrication of silver nanoparticles ring templated by plasmid DNA. Applied Surface Science, 2006,252: 4969-4974.（SCI）
47) Lanlan Sun, Gang Wei, Yonghai Song, Zhiguo Liu, Li Wang, Zhuang Li. Solution-phase synthesis of Au@ZnO core-shell composites. Materials Letters,2006,60: 1291-1295.（SCI）
48) YongHai. Song，Zhuang Li, Zhiguo Liu，Gang Wei, LiWang, Lanlan Sun，Cunlan Guo, Yujing Sun, TaoYang, A Novel Strategy to Construct a Flat-Lying DNA Monolayer on a Mica Surface ,J. Phys. Chem. B ,2006,110 :10792-10798.（SCI）
49) 祖元刚,张宇亮,刘志国,王延兵,梁慧丽,刘红梅.原子力显微镜在植物学研究中的应用. 植物学通报, 2006, 23:708-717.
50) Zhiguo Liu, Zhuang Li, Hualan Zhou, Gang Wei, Yonghai Song, Li Wang. Imaging DNA molecules on mica surface by atomic force microscopy in air and in liquid. Microscopy Research and Technique, 2005, 66:179-185.（SCI）
51) Zhiguo Liu, Zhuang Li, Hualan Zhou, Gang Wei, Yonghai Song, Li Wang. Immobilization and condensation of DNA with 3-aminopropyltriethoxysilane studied by atomic force microscopy. Journal of Microscopy-Oxford, 2005, 218,233-239. （SCI）
52) Zhiguo Liu, Zhuang Li, Hualan Zhou, Gang Wei, Yonghai Song, Li Wang. Mechanical engraving mica surface using the atomic force microscopy tip facilitates returned to a specific sample location. Microscopy Research and Technique, 2005,66:156-162.（SCI）
53) Zhiguo Liu, Zhuang Li, Hualan Zhou, Gang Wei, Yonghai Song, Li Wang. Observation of the mica surface by atomic force microscope. Micron,2005, 36:525-531.（SCI）
54) Jie Zhang, Zhiguo Liu, Jun Lin, and Jiye Fang. Y2O3 Microprisms with Trilobal Cross Section. Crystal Growth & Design, 2005,5:1527-1530.（SCI）
55) Jie Zhang, Zhiguo Liu, Cuikun Lin, Jun Lin.A simple method to synthesize b-Ga2O3 nanorods and their photoluminescence properties. Journal of Crystal Growth, 2005,280:99-106.（SCI）
56) Gang Wei, Hualan Zhou, Zhiguo Liu, Yonghai Song, Li Wang，Lanlan Sun, and Zhuang Li. One-Step Synthesis of Silver Nanoparticles, Nanorods and Nanowires on the Surface of DNA Network.J. Phys. Chem. B , 2005 ,109:8738-8743. （SCI）
57) Gang Wei, Li Wang, Zhiguo Liu, Yonghai Song, Lanlan Sun, Tao Yang, and Zhuang Li. DNA-Network-Templated Self-Assembly of Silver Nanoparticles and Their Application in Surface-Enhanced Raman Scattering. J. Phys. Chem. B, 2005,109 :23941-23947.（SCI）
58) Gang Wei, Li Wang，Hualan Zhou, Zhiguo Liu, Yonghai Song, Li Wang，Lanlan Sun, and Zhuang Li.Electrostatic assembly of CTAB-capped silver nanoparticles along predefined λ-DNA template. Applied Surface Science, 252:1189-1196,2005. （SCI）
59)Yonghai Song, Zhuang Li, Zhiguo Liu, Gang Wei, Li Wang, Lanlan Sun. Immobilization of DNA on 11-Mercaptoundecanoic acid-modified gold (111) surface for atomic force microscopy imaging. Microscopy Research and Technique, 2005,68:59-64.（SCI）
60) Gang Wei, Hualan Zhou, Zhiguo Liu, Zhuang Li. A simple method for the preparation of ultrahigh sensitivity surface enhanced raman scattering (SERS) active substrate Applied Surface Science ,2005, 240:260-267. （SCI）
61)周化岚，魏刚，刘志国，王丽，宋永海，李壮. Direct Construction of Poly-L-lysine Nanostructure by Dip-pen Nanolithography. 高等化学学报, 2005,26 :757-759.（SCI）
62)Hualan Zhou, Zhuang Li, Aiguo Wu, Gang Wei, Zhiguo Liu. Direct patterning of rhodamine 6G moleculeson mica by dip-pen nanolithography. Applied Surface Science, 2004 ,236:18-24.（SCI）
