李妍妍,女,1986年生,中共党员,工作于东北林业大学化学化工与资源利用学院,生药学学科,副教授,硕士生导师。先后于东北林业大学获得农学学士学位(动物医学),吉林大学获得理学硕士学位(生物化学于分子生物学),哈尔滨工业大学获工学博士学位(生物医学工程)。2017年通过高层次引进人才项目,以“优秀青年学者”层次进入东北林业大学工作,任黑龙江省植物学会理事。目前主持国家自然科学基金、“十三五”国家重点研发计划子课题、国家林业和草原局动植物司基金、中央高校基本科研业务基金等课题7项,总经费124万。在Bioconjugate Chemistry、Materials Science & Engineering C、RSC Advances、Advanced Functional Materials、Biomaterials、Nanoscale等国际重要刊物上累计发发表SCI论文13篇,总影响因子89.466。邮箱地址:liyanyan_ls@126.com
一、主要研究方向:
主要从事纳米药物递送系统、多功能诊疗制剂、天然活性物质的纳米抗肿瘤制剂、纳米抗菌材料等研究。
二、讲授课程:
研究生课程:药物递送理论与技术,32学时
纳米药物评价技术,32学时
本科课程:大学化学,32学时
三、主持项目:
1. 国家自然科学基金委:中空钨酸铋载药纳米粒用于光响应癌症联合治疗的研究;2020.01-2022.12; 22万元;在研;主持;
2.东北林业大学优秀青年学者启动基金:2017.07-2021.07; 40万元;在研;主持;
3. “十三五”国家重点研发计划:紫杉醇缓控释制剂的研究;2017/07-2020/12;20万元;在研;主持;
4.中央高校基本科研业务费专项资金项目:多功能靶向纳米粒子用于递送紫杉醇研究;2018/05-2020/05;9万元;在研;主持;
5.国家林业和草原局动植物司:两种赛加羚羊角的成分分析与鉴定技术研究;2020.01-2020.12; 10万元;在研;主持;
6.国家林业和草原局动植物司:象鼻蓝的保护策略研究;2020.01-2022.12; 15万元;在研;主持;
7.国家林业和草原局动植物司:东北红豆杉繁育状况调查监测及监管对策研究;2020.07-2022.07; 8万元;在研;主持;
四、代表论文
1. Na Guo, Feng Cang, Zhen Wang, Ting-Ting Zhao, Xin-Rui Song, Stefano Farris, Yan-Yan Li*, Yu-Jie Fu*, Magnetism and NIR dual-response polypyrrole-coated Fe3O4 nanoparticles for bacteria removal and inactivation, Materials Science & Engineering C,2021;126;112-143. SCI收录(IF:7.328, JCR-Q1区)
2. Kou Ping, Kang Yufei, Wang Li-Tao, Niu Li-Jun, Xiao Ying, Guo Na, Cui Qi, Li Yan-Yan,* Yu-Jie Fu,** An integrated strategy for production of four anthocyanin compounds from Ribes nigrum L. by deep eutectic solvents and flash chromatography, Journal of Industrial and Engineering Chemistry. 2019;80;614-625. SCI收录(IF:5.278, JCR-Q1区)
3. Guo Na, Jiang Yiwei, Kou Ping, Liu Zhiming, Efferth Thomas, Li Yanyan*, Fu Yujie*. Application of integrative cloud point extra and concentration for the analysis of polyphenols and alkaloids in mulberry leaves. Journal of pharmaceutical and biomedical analysis. 2019; 167:132-9.SCI收录(IF:3.935, JCR-Q2区)
4. Jin Yushen#, Li Yanyan#(共同第一作者), Yang Xin, Tian Jie. Neuroblastoma-targeting triangular Gadolinium oxide nanoplates for precise excision of cancer. AMRIa biomaterialia. 2019; 87:223-34. SCI收录(IF:8.947, JCR-Q1区)
5. Li Yanyan, Wu Yidi, Zheng Shuquan, Liang Xiaolong, Liang Zicai. PEGylated cationic hybrid bicellar nanodisc for efficient siRNA delivery. Rsc Adv. 2016; 6(114):113745-53. SCI收录(IF: 3.361, JCR-Q2区)
6. Liang Xiaolong#, Li Yanyan#(共同第一作者), Li Xiaoda, Jing Lijia, Deng Zijian, Yue Xiuli, Li Changhui, Dai Zhifei. PEGylated Polypyrrole Nanoparticles Conjugating Gadolinium Chelates for Dual-Modal MRI/Photoacoustic Imaging Guided Photothermal Therapy of Cancer. Adv FunMRI Mater. 2015; 25(9):1451-62. SCI收录(IF:18.808, JCR-Q1区)
7. Li Yanyan, Zheng Shuquan, Liang Xiaolong, Jin Yushen, Wu Yidi, Bai Huichen, Liu Renfa Dai Zhifei, Liang Zicai, Shi Tiejun. Doping Hydroxylated Cationic Lipid into PEGylated Cerasome Boosts in Vivo siRNA Transfecion Efficacy. BioconjuCelte Chem. 2014; 25(11):2055-66. SCI收录(IF:4.774, JCR-Q1区)
8. Jin Yushen, Li Yanyan, Ma Xibo, Zha Zhengbao, Shi Liangliang, Tian Jie, Dai Zhifei. Encapsulating tantalum oxide into polypyrrole nanoparticles for X-ray MRI/photoacoustic bimodal imaging-guided photothermal ablation of cancer. Biomaterials. 2014; 35(22):5795-804. SCI收录(IF:12.479, JCR-Q1区)
9. Jin Yushen, Li Yanyan, Pan Hongjie, Dai Zhifei. Liposomal nanohybrid cerasomes for controlled insulin release. Rsc Adv. 2014; 4(81):42808-15. SCI收录(IF: 3.361, JCR-Q2区)
10. Jin Yushen, Pan Hongjie, Li Yanyan, Dai Zhifei. Chitosan modified cerasomes incorporating poly (vinyl pyrrolidone) for oral insulin delivery. Rsc Adv. 2014; 4(102):58137-44. SCI收录(IF: 3.361, JCR-Q2区)
11. Fu Guanglei, Liu Wei, Li Yanyan, Jin Yushen, Jiang Lingdong, Liang Xiaolong, Feng Shanshan, Dai Zhifei. Magnetic Prussian Blue Nanoparticles for Targeted Photothermal Therapy under Magnetic Resonance Imaging Guidance. Bioconjugate Chem. 2014; 25(9):1655-63. SCI收录(IF:4.774, JCR-Q1区)
12. Zha Zhengbao, Deng Zijian, Li Yanyan, Li Changhui, Wang Jinrui, Wang Shumin, Qu Enze,Dai Zzhifei. Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging. Nanoscale. 2013; 5(10):4462-7.SCI收录(IF:7.79, JCR-Q1区)
13. Zha Zhengbao, Zhang Shuhai, Deng Zijian, Li Yanyan, Li Changhui, Dai Zhifei. Enzyme-responsive copper sulphide nanoparticles for combined photoacoustic imaging, tumor-selective chemotherapy and photothermal therapy. Chem Commun. 2013;49(33):3455-7.SCI收录(IF:6.222, JCR-Q1区)